Sarah Sammons, Breast Medical Oncologist and Senior Physician at Dana-Farber’s Breast Oncology Center, shared a post on LinkedIn:
“Sharing that our new paper on de novo oligometastatic breast cancer (OMBC) treated with curative intent has just been published:
“Outcomes of patients with de novo oligometastatic breast cancer treated with curative intent at a single institution”
In this single-institution retrospective study (2007–2023), we examined a highly selected cohort of 39 patients who:
Presented with de novo oligometastatic breast cancer (1 organ, ≤4 metastatic lesions), were treated with physician-expressed curative intent, received definitive breast surgery, modern systemic therapy, and, in most cases, metastasis-directed therapy (MDT).
Demographics: 12 hormone receptor-positive (HR+)/HER2+, 2 HR-negative (HR-)/HER2-, 21 HR+ /HER2-, and 4 HR-/HER2+ . Thirty-three patients (84.6%) had 1 metastasis at diagnosis. Median age was 47 years (28-69). Most received neoadjuvant therapy.
Key findings:
- 5-year overall survival: 77%
- 5-year recurrence-free survival: 58%
All recurrences were new distant metastases
Outcomes were similar between HER2+ and HR+/HER2- subtypes
We did not observe a clear RFS benefit from MDT in this small cohort, underscoring the need for larger prospective trials
While this is a small, highly selected group and not practice-changing on its own, the results support the idea that a subset of patients with OMBC may achieve prolonged disease-free survival with multimodal, curative-intent strategies.
We argue that this justifies boldly designed prospective trials specifically for patients with de novo OMBC, particularly those with HR+/HER2- or HER2+ disease.
Grateful to my co-authors and colleagues at DFCI for their collaboration on this work.
If you’re interested in oligometastatic disease, MDT, or curative-intent approaches in stage IV breast cancer, I’d welcome your thoughts and discussion.”
Title: Outcomes of patients with de novo oligometastatic breast cancer treated with curative intent at a single institution
Authors: Emily Chen, Hillary Heiling, Tianyu Li, Jennifer Bellon, Faina Nakhlis, Heather Parsons, Alyssa Martin, Harold Burstein, Sara Tolaney, Craig Snow, Nabihah Tayob, Lior Braunstein, Nancy Lin, Sarah Sammons
Read the full article.
More posts featuring Sarah Sammons.