Sanam Loghavi, Associate Professor of Pathology at MD Anderson Cancer Center, Medical Director of ECOG-ACRIN Leukemia Bank and Editor in Chief of Image Bank at the American Society of Hematology, shared a post on X:
“Long-term outcomes in FLT3-m AML with frontline HMA+VEN+FLT3 i
- 93% CR/CRi in ND FLT3-m AML.
- 3-yr OS: 45% (FLT3-ITD), 76% (FLT3-TKD).
- RASp mutations poor survival.
- ITD NGS MRD highly prognostic.
- FLT3 wild-type relapses common.”
Title: Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypomethylating agent, venetoclax and a FLT3 inhibitor
Authors: Nicholas J. Short, Sanam Loghavi, Musa Yilmaz, Omer Karrar, Kunhwa Kim, Courtney D. Dinardo, Tapan M. Kadia, Manuel Maroun, Gautam Borthakur, Ghayas C. Issa, Joseph Jabbour, Betul Oran, Elizabeth J. Shpall, Uday Popat, Keyur P. Patel, Mark Routbort, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian, Naval Daver
Read the Full Article in haematologica.
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