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Sakditad Saowapa: EGFR TKI Resistance in NSCLC – Key Mechanisms

Sakditad Saowapa, Oncologist at UI Holden Comprehensive Cancer Center, shared a post on X about a paper by Jing Zhao et al. published in the Nature:

“EGFR TKI Resistance in NSCLC — Key Mechanisms

Primary resistance

  • Often from uncommon EGFR mutations (e.g., ex20ins)
  • Or baseline MET/HER2 amp co-alterations

Acquired resistance

  • ~50% = no identifiable mechanism
  • Others fall into on-target, off-target, or biological transformation․”

Title: Navigating the landscape of EGFR TKI resistance in EGFR-mutant NSCLC — mechanisms and evolving treatment approaches

Authors: Jing Zhao, Wanting Xu, Fei Zhou, Xiangyu Zhang, Mo Zhou, Da Miao, Lan Yu, Yongchang Zhang, Junqiang Fan, Caicun Zhou, Wen Li, Tony Mok, Xiuning Le, Molly Li, Yang Xia

Read the Full Article in Nature.

Sakditad Saowapa

More posts featuring Sakditad “Tew” Saowapa.

Caicun Zhou cancer Da Miao Fei Zhou Jing Zhao Junqiang Fan Lan Yu Mo Zhou Molly Li Nature OncoDaily Oncology Sakditad Saowapa Tony Mok Wanting Xu Wen Li Xiangyu Zhang Xiuning Le Yang Xia Yongchang Zhang