Roni Shouval, Assistant Attending of Bone Marrow Transplantation and Cellular Therapy Service and Principal Investigator of Precision Cellular Therapy Research Group at Memorial Sloan Kettering Cancer Center, shared a post on X:
“Rethink CART neurotoxicity: Not just ICANS. Tumor-Inflammation-Associated Neurotoxicity (TIAN) is tied to tumor volume in CNS lymphoma. Bigger lesions? Higher TIAN risk. Distinguish from ICANS by focal symptoms”
Title: Clinical presentation, management, and outcome of TIAN in CNS lymphoma treated with CD19-CAR T-cell therapy
Authors: Leon D. Kaulen, Maria Martinez-Lage, Jeremy S. Abramson, Philipp Karschnia, Sofia Doubrovinskaia, Ganesh M. Shankar, Bryan D. Choi, Christopher M. Ramundo, Felix Ehret, Jeffrey A. Barnes, Areej El-Jawahri, Ephraim P. Hochberg, P. Connor Johnson, Jacob D. Soumerai, Scott R. Plotkin, Tracy T. Batchelor, Wolfgang Wick, Marcela V. Maus, Yi-Bin Chen, Matthew J. Frigault, Jorg Dietrich.
Other articles featuring Roni Shouval on OncoDaily.