Radiotherapy and Oncology shared a post on LinkedIn:
“Editor’s choice: Radiotherapy and Oncology (the Green Journal).
Can moderately hypofractionated radiotherapy be safely delivered after radical prostatectomy?
A phase II study from Japan evaluated a regimen of 54 Gy in 18 fractions in the adjuvant and salvage setting for prostate cancer. Among 55 patients, treatment demonstrated acceptable toxicity, quality of life was largely maintained, and the 3-year biochemical recurrence-free survival was 65.8.
Key highlights:
- 54 Gy in 18 fractions delivered with VMAT.
- Acute GU toxicity ≥ grade 2 in 5.5% of patients.
- Acute GI toxicity was predominantly grade 2 and transient.
- Quality of life remained largely stable following treatment.
- Three-year biochemical recurrence-free survival of 65.8%.
As interest in hypofractionation continues to grow, these prospective data add to the evolving evidence base for postoperative prostate radiotherapy and support the feasibility of shorter treatment schedules.”
Title: Safety and efficacy of moderately hypofractionated radiotherapy after radical prostatectomy: A phase II trial
Authors: Subaru Sawayanagi, Hideomi Yamashita, Taketo Kawai, Yusuke Sato, Atsuto Katano, Haruki Kume
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