Oscar Tahuahua Highlights KRAS–Occupation Link in NSCLC
Oscar Tahuahua, Medical Oncology Fellow at the National Cancer Institute of Mexico, shared a post on X about recent article by Roberto Serna-Blasco et al.:
“KRAS Mutation Status in NSCLC: Occupational Distribution
ATLAS subanalysis (n=302): Cooks 70% KRAS+ (OR=5.81), painters 66.7% (OR=4.29) vs 34% overall.
Sex/smoking adjusted, occupation leaves a genomic footprint.
KRAS by job:
• G12C: personal services 33.3% (p=0.012)
• G12A: painters 22.2% (p=0.020)
• G12D: chemical exposure 9.5% (p=0.005) Low exposure = ↓ KRAS (OR=0.43).
The carcinogen type shapes the mutational subtype.
KRAS+ in 87% of adenocarcinoma vs 61% KRAS wt; more often with synchronous tumors (p=0.035).”
Title: KRAS Mutation Status in Non-Small Cell Lung Cancer
Authors: Roberto Serna-Blasco, Karla Medina, María Ángeles Sala, David Aguiar, Asunción Díaz-Serrano, Mónica Antoñanzas, José Luis González Larriba, Julio Ocaña, Xabier Mielgo, Inmaculada Fernández, Rafael López-Castro, Manuel Cobo, Mireia Martínez, José Carlos Villa, Petra Rosado, Ana López, María Guirado, Santiago Viteri, Delvys Rodríguez, Florencia García, Soraya Simón, María Ángeles Moreno, Silvia Catot, Pilar Mediavilla, Natalia García Simón, Leonor Octavio, Virginia Calvo, Atocha Romero, Mariano Provencio
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