Nieves Martinez Lago, Specialist in the Field (FEA) of Medical Oncology at University Hospital Complex of Santiago de Compostela, shared a post on X:
“Very early (30-39y) vs early (40-49y) onset mCRC
- Worse OS: 30 vs 38 months
- More KRAS mut.
- Fewer APC alt.
- More peritoneal metastases (32% vs 20%)
- Patients aged 30–39 may represent a distinct, more aggressive subtype of EOCRC.”
Title: Distinct molecular and clinical aggressiveness in very early-onset metastatic colorectal cancer: survival and genomic divergence between patients aged 30-39 versus 40-49 years
Authors: A. Pretta, G. Rebecchi, G. Maddalena, F. Marmorino, P. Ziranu, F. Manoni, M.C. De Grandis, M. Carullo, P.A. Ferrari, C. Donisi, G. Randon, E. Perissinotto, A. Taravella, V. Nasca, F. Buggin, G. Pretta, P. Ciracì, F. Bergamo, C. Cremolini, S. Lonardi, M. Scartozzi, F. Pietrantonio
Read the Full Article on ESMO Open

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