Nieves Martinez Lago, Specialist in the Field (FEA) of Medical Oncology at University Hospital Complex of Santiago de Compostela, shared a post on X:
“CAPE dosing: black box?
- FDA: mandatory DPYD testing
- Complete DPD def. → avoid
- Partial def. (~5%) → individualize
- 25–50% dose reduction?
- Limited evidence
- PK/PD very variable (renal, sex, surgery…)
- Efficacy–exposure relation unclear
- Time to rethink CAPE dosing.”
Title: Dead Doctor: We Still Have No Idea of What Dose of Capecitabine You Should Prescribe
Authors: Mark J. Ratain, Peter H. O’Donnell
Other articles featuring Nieves Martinez Lago on OncoDaily.