Nicholas DeVito, Assistant Professor of Medicine at the Division of Medical Oncology at Duke University, shared a post on LinkedIn:
“If you are at AACR IO stop by and see our poster on the effects of chemotherapy on spatial immune relationships in the colorectal cancer microenvironment.
Unexpectedly, T cells and macrophages increase in nonresponders to FOLFOX, and NK cells increased in responders, while TANs were decreased in both populations. We have more to explore here with additional samples, spatial transcriptomics, and mouse correlates as we build an understanding of chemotherapy’s impact on anti-tumor inmunity.”
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