Nelson Dusetti, Head of the Translational Research and Innovative Therapies Department at the Cancer Research Centre of Marseille (CRCM), shared a post on LinkedIn:
“Happy to share a new publication from our group on pancreatic cancer!!
In this review, we discuss the complex role of cellular senescence in pancreatic ductal adenocarcinoma. While senescence is traditionally viewed as a protective mechanism limiting oncogenic transformation, growing evidence shows that in established tumors it can also promote tumor progression through stromal remodeling, immune suppression and therapy resistance.
Understanding this dual role may open new therapeutic opportunities by targeting senescent cells or their secretory programs.
This work is also the result of a long-standing Franco-Argentine scientific collaboration between researchers from the CRCM – Centre de Recherche en Cancérologie de Marseille and Institut Paoli-Calmettes in Marseille, together with colleagues from CONICET and the University of Buenos Aires.
As part of the Franco-Argentine Joint Laboratory for Pancreatic Cancer Research, Daniel Grasso recently spent time in our laboratory in Marseille, which provided the opportunity to work together on this review.
Science advances through collaboration.”
Title: When Defense Turns Dangerous: The Dual Nature of Senescence in Pancreatic Ductal Adenocarcinoma
Authors: Juan Iovanna, Nelson Dusetti, Daniel Grasso
Read the Full Article.
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