Nelson Dusetti, Head of the Translational Research and Innovative Therapies Department at the Cancer Research Centre of Marseille (CRCM), shared a post on LinkedIn:
“I am very pleased to share our new publication:
“Stage-Dependent Transcriptional Analysis Reveals Key Genes Driving Pancreatic Ductal Adenocarcinoma Progression and Therapeutic Vulnerabilities“.
It represents the first scientific publication of the Franco-Argentinian Network on Pancreatic Cancer, a long-term collaborative initiative established under the scientific leadership of Juan Iovanna (Inserm, CRCM) and bringing together CRCM – Centre de Recherche en Cancérologie de Marseille, Inserm / CNRS / Aix-Marseille University / Institut Paoli-Calmettes (IPC) in Marseille and major Argentinian partners including UBA and CONICET.
In this study, we analyzed 443 treatment-naïve human PDAC samples and generated a stage-resolved transcriptomic atlas spanning resectable disease to liver metastases.
Key findings:
- Identification of dynamic transcriptional programs evolving across clinical stages
- A metabolic transition from glycolytic profiles in early stages to increased mitochondrial and OXPHOS dependence in metastatic disease
- Progressive collapse of immune-stimulatory signals and establishment of an “immune-cold” microenvironment in advanced PDAC
- Compact early- and late-stage gene signatures validated in independent TCGA and ICGC cohorts
- Functional validation in patient-derived cultures showing increased invasiveness, redox imbalance, and mitochondrial dependency in advanced tumors
Beyond the data, this work reflects a shared vision: Building coordinated, progression-aware translational research in pancreatic cancer, integrating transcriptomics, tumor biology, patient-derived models, and clinical expertise across continents.
I would like to sincerely thank all co-authors who made this project possible.
And to all institutions supporting this Franco-Argentinian scientific bridge.
This is only the beginning!!
Pancreatic cancer progression is not a binary event, it is a dynamic biological trajectory. Understanding it stage by stage is essential if we want to design smarter and more effective therapeutic strategies.”
Title: Stage-Dependent Transcriptional Analysis Reveals Key Genes Driving Pancreatic Ductal Adenocarcinoma Progression and Therapeutic Vulnerabilities
Authors: Eduardo Chuluyan, Juan Iovanna, Brice Chanez, Analia Meilerman, Carla Remolins, Andrea Paes de Lima, Kevin Matamoros, Claudio Incardona, Diego Guerrieri, Gustavo Kohan, Florencia Gottardo, Martin Ledesma, Juan Garona, Carlos Davio, Agustin Yaneff, Ana Sahores, Daniel Grasso, Maria Noe Garcia, Daniela Papademetrio, Maria Eugenia Pasqualini, Luis Sarotto, Felix Gabriel Lezcano, Jonathan Garnier, Analia Pasqua, Oscar Mazza, Pascal Hammel, Nicolas Fraunhoffer, Nelson Dusetti
Read the Full Article.
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