Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day:
Iron-mediated ferroptosis impairs CAR-T cell function (by increasing mitochondrial reactive oxygen species and lipid peroxidation) and anti-tumor efficacy, which can be reversed by genetic ablation of ACSL4 in CAR-T cells.”
Title: Iron-mediated ferroptosis impairs CAR-T cell function and antitumor efficacy
Authors: Delin Kong, Tingting Yang, Mengyu Zhao, Lin Yang, Ruirui Jing, Youqin Feng, Shaohui Shi, Zhouning Lin, Shi Han, Cong Wei, Rongrong Chen, Qiqi Zhang, Jiazhen Cui, Tianning Gu, Xiujian Wang, Xia Li, Ye Meng, Xiaolin Yuan, Mingming Zhang, Linghui Zhou, Houli Zhao, Ruimin Hong, Simao Huang, Mi Shao, Xiaohui Si, Yingli Han, Shufen Wang, Xiangjun Zeng, Dawei Huo, Meng Zhang, Kejia Hu, Zenan Cen, Haiqiong Zheng, Guoqing Wei, Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang
You can read the Full Article on Nature Cancer.
You can find other articles featuring Robert Orlowski on OncoDaily.
