Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day:
Study of dynamics of BCMA expression in RRMM pts w/ BCMA-directed CAR-T finds lower expression at relapse by flow vs baseline (p=0.04); down-regulation in 50% (8/16); higher expression correlated w/ deep/durable responses․”
Title: Dynamics of BCMA expression in patients with relapsed/refractory multiple myeloma receiving BCMA-directed CAR-T therapy
Authors: Masooma Shifa Rana, Sebastian Fernandez-Pol, Alexandria Jensen, Vanna Hovanky, Arash Velayati, Jean S. Oak, Oscar Silva, Erik Ames, Lori S. Muffly, Bita Sahaf, Sally Arai, Vanessa E. Kennedy, Sushma Bharadwaj, David J. Iberri, Michaela Liedtke, Yasodha Natkunam, Parveen Shiraz, Wen-Kai Weng, Melody Smith, Matthew J. Frank, Crystal L. Mackall, Saurabh Dahiya, Lekha Mikkilineni, David B. Miklos, Hitomi Hosoya, Surbhi Sidana
You can read the Full Article in Blood Cancer Journal.
You can find other articles featuring Robert Orlowski on OncoDaily.
