Mostafa Faisal, Adjunct Assistant Professor at Alfaisal University, shared a post on X about a paper published by Krzysztof Kalwak et. al in Bone Marrow Transplantation:
“Defibrotide for prophylaxis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in pediatric high-risk patients: consensus guidelines from the European Society for Blood and Marrow Transplantation (EBMT).
EBMT 2026 Consensus: Defibrotide (DF) Prophylaxis for SOS/VOD:
- SOS/VOD incidence in pediatric HSCT up to 15–20%, high mortality.
- Meta-analysis: DF prophylaxis low SOS/VOD risk (RR 0.30).
Prospective trials showed conflicting results; Harmony trial had major limitations. - EMA DHPC advised against DF prophylaxis leads to concern for high-risk children, especially infants.
- EBMT experts endorse DF prophylaxis in high-risk pediatric patients.
- New weighted risk score supports individualized DF prophylaxis decisions.”
Title: Defibrotide for prophylaxis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in pediatric high-risk patients: consensus guidelines from the European Society for Blood and Marrow Transplantation (EBMT).
Authors: Selim Corbacioglu, Rajinder Bajwa, Ali Bülent Antmen, Adriana Balduzzi, Jaap Jan Boelens, Francesca Bonifazi, Simone Cesaro, Fabio Ciceri, Antonio Colecchia, Fiona Dignan, Katharina Kleinschmidt, Kris M. Mahadeo, Antonio Pagliuca, Petr Sedlacek, Peter J. Shaw, Jerry Stein, Zofia Szmit, Francesco Tambaro, Elif Ince, Marta Verna, Akif Yesilipek, Marco Zecca, Paul G. Richardson, Mohamad Mohty and Krzysztof Kalwak.
You can read the full article in Bone Marrow Transplantation.
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