John Gordon, co-Founder, Director, VP Scientific Affairs at Celentyx Ltd, shared on LinkedIn:
“Unravelling its Paradoxical Contribution to Tumour Immunosurveillance and Evasion
Open Access Review Dives Deep into Immunotherapy Implications
Mitochondrial lipid metabolism plays a pivotal role in tumor immunosurveillance and immune evasion.
This review by Ana Belén Plata Gómez, et al explores how mitochondrial regulation shapes immune cell metabolism within the tumor microenvironment (TME), focusing on the antitumor effects of the mitochondrial-fueled immune response and the detrimental impact of impaired mitochondrial function on immune cell cytotoxicity.
Although current studies support this dual role, critical gaps remain, including how immune cells adapt differently to the lipid-rich TME, and how therapies can target lipid metabolism without harming immune memory.
By synthesizing current findings and highlighting these uncertainties, this review highlights mitochondrial lipid metabolism as a promising therapeutic axis in cancer immunotherapy.”
Title: Mitochondrial lipid metabolism in tumor immunosurveillance and evasion
Journal: Trends in Immunology
Authors: Ana Belén Plata-Gómez, Weixin Chen, Ping-Chih Ho, Guang Sheng Ling
More from John Gordon on OncoDaily.