Mitochondrial Lipid Metabolism
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John Gordon on Mitochondrial Lipid Metabolism as a Therapeutic Target in Cancer

John Gordon, co-Founder, Director, VP Scientific Affairs at Celentyx Ltd, shared on LinkedIn:

“Unravelling its Paradoxical Contribution to Tumour Immunosurveillance and Evasion

Open Access Review Dives Deep into Immunotherapy Implications

Mitochondrial lipid metabolism plays a pivotal role in tumor immunosurveillance and immune evasion.

This review by Ana Belén Plata Gómez, et al explores how mitochondrial regulation shapes immune cell metabolism within the tumor microenvironment (TME), focusing on the antitumor effects of the mitochondrial-fueled immune response and the detrimental impact of impaired mitochondrial function on immune cell cytotoxicity.

Although current studies support this dual role, critical gaps remain, including how immune cells adapt differently to the lipid-rich TME, and how therapies can target lipid metabolism without harming immune memory.

By synthesizing current findings and highlighting these uncertainties, this review highlights mitochondrial lipid metabolism as a promising therapeutic axis in cancer immunotherapy.”

Read further.

Mitochondrial Lipid Metabolism

Title: Mitochondrial lipid metabolism in tumor immunosurveillance and evasion

Journal: Trends in Immunology

Authors: Ana Belén Plata-Gómez, Weixin Chen, Ping-Chih Ho, Guang Sheng Ling

Read the full article.

John Gordon on Mitochondrial Lipid Metabolism as a Therapeutic Target in Cancer

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