Miriam Merad, the Director of the Precision Immunology Institute (PrIISM) at the Mount Sinai School of Medicine and Director of Mount Sinai’s Human Immune Monitoring Center (HIMC), shared a post on LinkedIn:
“Thrilled to see our new paper led by the outstanding Brown Lab, now out in Nature Biotechnology.
We provide mechanistic insights into how mRNA vaccines work – challenging key assumptions and offering new ways to control vaccine activity.
Big takeaway is that cellular expression patterns matter.
mRNA expression in hepatocytes and myocytes shapes the immune response. Surprisingly, direct expression in dendritic cells is not required, as antigen can be transferred to them.
This has major implications for mRNA vaccine and drug design.
Grateful to Yizhou Dong, Joshua Brody, Alessia Baccarini, Adam Marks, Sophia Siu for all the hard work and for the fun collaboration.”
Joshua Brody, Associate Professor, Division of Hematology and Oncology at Icahn School of Medicine at Mount Sinai, shared a post by Miriam Merad on LinkedIn, adding:
“Really elegant work that should transform the way the field is thinking about how to improve mRNA vaccines for infections and cancer!”
Title: mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression
Authors: Adam Marks, Sophia Siu, Filippo Bianchini, Chunxi Wang, Ashwitha Lakshmi, Matthew Phelan, Andrew Zhu, Chang Moon, Judit Morla-Folch, Abraham J. P. Teunissen, Angelo Amabile, Alessia Baccarini, Miriam Merad, Joshua D. Brody, Yizhou Dong, Brian D. Brown
Read the article: here.”
Other articles featuring Miriam Merad on OncoDaily.