Masahiro Torasawa, Medical Oncologist at Juntendo University, shared a post on X:
“A ‘blood-brain barrier-like’ vascular gate limits immunotherapy efficacy in neuroendocrine cancers.
Blood vessels in SCLC form a ‘blood-brain barrier-like vascular gate (BVG)’ with thick basement membranes, tight junctions, and pericyte coverage.
The BVG acts as a physical barrier, restricting CD8+ T cell infiltration and causing the ‘immune desert’ phenotype”
Title: A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers
Authors: Yiyun Wang, Ailing Zhong, Bo Wang, Xiaoqian Zhai, Chang Lei, Zuoyu Liang, Xintong Deng, Jian Zhong, Chaoxin Xiao, Jianan Zheng, Baohong Wu, Lanxin Zhang, Yuying Wang, Xiangmeng Luo, Jian Wang, Mengsha Zhang, Hongyu Liu, Xudong Wan, Siqi Dai, Yucen Yang, Shiyu Zhang, Weiya Wang, Shengyong Yang, Jianxin Xue, Chengjian Zhao, Tuomas Tammela, Zhiming Li, Yan Zhang, Feifei Na, Manli Wang, Yu Liu, Chong Chen
Other articles featuring Masahiro Torasawa on OncoDaily.
