Mark Lewis: How the CHALLENGE Study Restores Agency to Colon Cancer Patients
Aug 30, 2025, 23:45

Mark Lewis: How the CHALLENGE Study Restores Agency to Colon Cancer Patients

Mark Lewis, Director of Gastrointestinal Oncology at Intermountain Healthcare in Utah, shared a post on X by NEJM, adding:

“I love how the CHALLENGE study can restore agency to patients after cancer has shifted their locus of control.

It’s not just vague advice to ‘be more fit’; it’s a specific, attainable increase in METs with a survival benefit on par with at least one of our adjuvant chemo drugs.”

Quoting NEJM‘s post:

“Could a structured exercise program after undergoing adjuvant chemotherapy for colon cancer improve survival and quality of life?

The latest video in our partnership with Dr. Glaucomflecken (Will Flanary) summarizes new research.

Access the article for free.”

Watch the video attached to this post.

Title: Structured Exercise after Adjuvant Chemotherapy for Colon Cancer

Journal: NEJM

Author: Kerry S. Courneya, Janette L. Vardy, Christopher J. O’Callaghan, Sharlene Gill, Christine M. Friedenreich, Rebecca K.S. Wong, Haryana M. Dhillon, Victoria Coyle, Neil S. Chua, Derek J. Jonker, Philip J. Beale, Kamal Haider, Patricia A. Tang, Tony Bonaventura, Ralph Wong, Howard J. Lim, Matthew E. Burge, Stacey Hubay, Michael Sanatani, Kristin L. Campbell, Fernanda Z. Arthuso, Jane Turner, Ralph M. Meyer, Michael Brundage, Patti O’Brien, Dongsheng Tu, Christopher M. Booth

Read the full article.

Mark Lewis

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