Marc Hilmi, Medical Oncologist at Memorial Sloan Kettering Cancer Center, shared a post on X:
“Just back from AACR and honored to present our POLAR translational work led by the best mentors ever Wungki Park, Eileen M O’Reilly, Chris Iacobuzio.
Using single-cell, spatial transcriptomics and TCRseq, we dissect durable response vs rapid progression in PDAC Memorial Sloan Kettering Cancer Center.”
Wungki Park, Assistant Attending at Memorial Sloan Kettering Cancer Center, shared a post by Marc Hilmi, adding:
“Super-exciting work from our most creative physician-scientist Marc Hilmi from sPARKlab and Joshua Schoenfeld spearheading the multi-omic analyses in Precision Immunotherapy POLAR.
Getting to the core immune biology of the longitudinal tumor and blood TCR at single cell and spatial level.
Invigorating pre-existing Tumor-Infiltrating Expandable (TIE) T cell clonotypes in exceptional responders with dual PARP-PD-1 blockade in HRD PC Fascinating story of spatial TCR offering deep and orthogonal insight from genomically the most immunogenic subset of pancreatic cancer.”
Title: Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial
Authors: Wungki Park, Catherine A. O’Connor, Joanne F. Chou, Marc Hilmi, Zeynep Tarcan, Carly Schwartz, Mary Larsen, Ramzi Homsi, Karthigayini Sivaprakasam, Shigeaki Umeda, Maria A. Perry, Anna M. Varghese, Kenneth H. Yu, Fiyinfolu Balogun, Alice Zervoudakis, Seth S. Katz, Tae-Hyung Kim, Ken Zhao, Allison L. Richards, Nicolas Lecomte, Daniel Martin Muldoon, Elias Karnoub, Walid Chatila, Jessica Yang, Imane El-Dika, Devika Rao, Smita Joshi, Michael B. Foote, Ryan Sugarman, James J. Harding, Andrew S. Epstein, David Kelsen, Sree Chalassani, Fergus Keane, Joshua D. Schoenfeld, Anupriya Singhal, Erin Diguglielmo, Chaitanya Bandlamudi, Junmin Song, Hulya Sahin Ozkan, Junguei Hong, Haochen Zhang, Agustin III Cardenas, Maria Lao, Jerry Melchor, Ronak Shah, Wenfei Kang, Francesca Mazzoni, Kevin Soares, Mark TA Donoghue, Ernesto Santos, Vineet Rolston, Marsha Reyngold, Alice Chia-chi Wei, Murray Tipping, Olca Basturk, Michael Berger, Richard Kihn Do, Mark Schattner, William R. Jarnagin, Nadeem Riaz, Vinod Balachandran, Dana Pe’er, Marinela Capanu, Christine Iacobuzio-Donahue, Eileen M. O’Reilly
Read the full article here.
Other articles featuring Marc Hilmi on OncoDaily.