Mali Barbi, Medical Oncologist at Northwell Health, shared a post on X:
“Solid tumor CAR-T has been hitting a wall. The “Trojan Horse” study from Brian Brown Lab (Icahn School of Medicine at Mount Sinai) just published in Cancer Cell is a necessary shift in strategy. Instead of targeting the tumor directly, they targeted the “guards” (TAMs) using FOLR2/TREM2 CAR-Ts armored with IL-12.
The result? A total TME reset from immunosuppressive to pro-inflammatory. For aggressive diseases like Uterine Carcinosarcoma, where the TME is a fortress, we have to start targeting the “neighborhood” not just the “house.”
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor….
Title: Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
Authors: Jaime Mateus-Tique, Ashwitha Lakshmi, Bhavya Singh, Rhea Iyer, Alfonso R. Sánchez-Paulete, Chiara Falcomatà, Matthew Lin, Gvantsa Pantsulaia, Alexander Tepper, Trung Nguyen, Angelo Amabile, Gurkan Mollaoglu, Luisanna Pia, Divya Chhamalwan, Jessica Le Berichel, Hunter Potak, Marco Colonna, Alessia Baccarini, Joshua Brody, Miriam Merad, Brian D. Brown
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More posts featuring Mali Barbi on OncoDaily.