Liang Cheng, President of International Society of Urological Pathology, Vice Chair for Translational Research at the Warren Alpert Medical School of Brown University, shared on LinkedIn:
”What Histologic Features Predict Mismatch Repair Deficiency in Endometrial Endometrioid Carcinoma?
Delighted to share this article, recently published in Pathology – Research and Practice, led by Drs. Marketkar and Caindec Brown Pathology. Our investigation demonstrates that routine histopathologic evaluation can help identify tumors likely to harbor MLH1/PMS2 deficiency.
Five morphologic features were evaluated:
- microacinar architecture
- intraluminal acute inflammation
- ntraluminal necrosis
- extraluminal acute inflammation
- and a dense peritumoral lymphoid response.
The presence of three or more of these features predicted MMR deficiency with an 80.6% positive predictive value and 85% specificity, with moderate interobserver agreement. These findings support a practical, cost-effective approach for triaging cases for MMR testing, particularly in resource-limited settings where universal testing may not be feasible.
Honored to be part of this study!”
Title: Histological predictors of mismatch repair deficiency in endometrial endometrioid carcinoma
Authors: Angelica Marisse S. Caindec, M. Ruhul Quddus, Kamaljeet Singh, Sadeq Islam, Padmini Manrai, C. James Sung, Liang Cheng, Shivali Marketkar
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