Liang Cheng, Director of Anatomic Pathology and Director of Molecular Pathology at Lifespan Academic Medical Center, Vice Chair for Translational Research at the Warren Alpert Medical School of Brown University, and President at the International Society of Urological Pathology, shared a post on LinkedIn:
“Happy to share this comprehensive review on Genomic Profiling of Upper Tract Urothelial Carcinoma (UTUC), authored by Professor Ali Amin (PMID: 40820359).
Upper tract urothelial carcinoma remains a clinically important yet comparatively understudied malignancy, making this a timely and valuable contribution to the field. This review highlights that while UTUC and Urothelial carcinoma of the bladder share many genetic alterations, they often differ in frequency and biologic context. These genomic differences may help explain distinct phenotypic and clinical behaviors, supporting the concept that UTUC and bladder cancer, despite similarities, are biologically different diseases that require disease-specific approaches.
The article also emphasizes the urgent need for large, dedicated next-generation sequencing studies focused specifically on UTUC across diverse patient populations, rather than combining data with bladder tumors. Better genomic characterization will help guide precision oncology, improve biomarker-driven treatment decisions, and support standardized testing strategies.
Particularly important areas for future study include therapeutically relevant alterations such as ERBB2, ERCC2, mismatch repair–related and Lynch syndrome-associated UTUC, as well as newly identified variants of uncertain significance.
Check it out.”
Title: Genetic profiling of upper tract urothelial carcinoma: A necessity for precision medicine
Authors: Ali Amin, Fatemeh Khalatbari, Liang Cheng
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