Kyle Smith, Principal Bioinformatics Scientist at St. Jude Children’s Research Hospital, shared a post on LinkedIn:
“I am excited to announce the publication of our newest method, M-PACT, in Nature Cancer today! Using this AI driven approach we can sift through cell-free DNA and classify brain tumors based on the methylation patterns even with tiny amounts of material. This is an achievement that could only be accomplished by collaborating with scientists from across the world and across disciplines. I am proud be part of such a collaborative team pushing the ball forward for noninvasive diagnostics!
Congratulations to the whole team including Tom Fischer, Katie Han, Paul Northcott, PhD, Kristian Pajtler, Kendra Maass!
Anyone interested in running this tool visit here
Run it even on a laptop! And send me comments or suggestions for improvements.”
Title: M-PACT Leverages Cell-Free DNA Methylomes to Achieve Robust Classification of Pediatric Brain Tumors
Authors: Kyle S. Smith, Tom T. Fischer, Katie Han, Anna Kostecka, Hong Lin, Daniel Senfter, Taha Soliman, Natalia Stepien, Stefanie Volz, Nathalie Schwarz, Tatjana Wedig, Sibylle Madlener, Christine Haberler, Sandeep K. Dhanda, Santhosh A. Upadhyaya, Patrick R. Blackburn, Maria T. Schmook, Judith de Bont, Hannu Haapasalo, Justina Dargvainiene, Frank Leypoldt, Stefan M. Pfister, Esther Hulleman, Brent A. Orr, Amar Gajjar, Giles W. Robinson, Joonas Haapasalo, Kristiina Nordfors, Johannes Gojo, Kristian W. Pajtler, Kendra K. Maass, Paul A. Northcott.
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