Katy Beckermann, Medical Director of GU Clinical Research at Tennessee Oncology, shared a post on X:
“Kimryn Rathmell shared a model on metabolic determinants of cancer metastasis at AACR Kidney 2026
The model: programmed tumor metabolism is tightly linked to metastatic potential in ccRCC.
High NDUFA4L2 expression forces a shift to low ox-phos leading to succinate depleted, which leads to DNA and histone demethylation resulting in epigenetic reprogramming that enables metastasis.
The dynamic shift in metabolism is not just a consequence of malignancy. It is the mechanism driving spread.”
Other articles featuring Katy Beckermann on OncoDaily.
