Katherine Aird, Professor at The Wistar Institute And the Principal Investigator at Aird Lab, shared a post on X:
“It’s time to rewrite reviews – aKG doesn’t just regulate demethylation. Work from my lab and Nathaniel Snyder demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja!
Thank you to so many collaborators and colleagues: Ben Bitler, Nadine Hempel, Raquel Buj, Naveen Kumar Tangudu, Erika Dahl and so many not on here: Katy Wellen, Francesmary Modugno, David Long, Chris Bakkenist, Simone Sidoli, and many more!
This work could not have been done with support from National Cancer Institute, American Cancer Society, and The Sandy Rollman Foundation. Also institutional support from UPMC Hillman Cancer Center and The Wistar Institute.”
Title: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
Authors: Apoorva Uboveja, Baixue Yang, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan R. Cole, Julie A. Disharoon, Richard S. Fang, Evan Levasseur, Miho Naruse, Zhentai Huang, Emily Megill, Daniel S. Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M. Marcinkiewicz, Sarah Graff, Ellen De Pieri, Andrea Andress Huacachino, Frank P. Vendetti, Jeff Danielson, Erika S. Dahl, Jennifer L. Pennise, Esther Elishaev, Alison Jaccard, Lauren Borho, Miriam D. Post, Kristine Cooper, Francesmary Modugno, Nadine Hempel, Wayne Stallaert, Christopher J. Bakkenist, Simone Sidoli, Kathryn E. Wellen, Benjamin G. Bitler, David T. Long, Nathaniel W. Snyder, Katherine M. Aird
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