Kamal S. Saini: Promising Neoadjuvant Results for Olaparib in ER-low, BRCA-Mutated Breast Cancer
Kamal S. Saini/LinkedIn

Kamal S. Saini: Promising Neoadjuvant Results for Olaparib in ER-low, BRCA-Mutated Breast Cancer

Kamal S. Saini, Executive Medical Director and Head of European Oncology Team at Fortrea, shared a post on LinkedIn:

“Presented by Nadine Tung at the 2025 San Antonio Breast Cancer Symposium, the OlympiaN study NCT05498155 reported a pathological complete response rate of 68–80% in patients with early-stage ER-low, HER2-negative, BRCA-mutated breast cancer treated with neoadjuvant olaparib ± durvalumab, highlighting the potential activity of PARP inhibition with or without immunotherapy in this biologically distinct subgroup.

Full Abstract.”

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Medically reviewed Dec 15, 2025 by Marine Rushanyan, MD