Julio Aguirre-Ghiso, Rose C. Falkenstein Chair in Cancer Biology at Albert Einstein College of Medicine, shared a post on LinkedIn:
“Interesting study that shows that in the end tumor growth taps into the inbuilt system robustness of metabolic pathways created by millions of years of evolution with the ultimate goal of survival for reproduction. GART was ultimately a signal, not entirely surprising.
It may be cool to look next at how actually instructive signals from the different niches studied (organs or even sites within organs) activate or not the metabolic pathways used (rather than nutrient availability) and how they change or not during early stages of metastatic initiation (dormancy and awakening) vs. large metastatic lesions. Congrats.”
Title: Nutrient requirements of organ-specific metastasis in breast cancer
Authors: Keene Abbott, Sonu Subudhi, Raphael Ferreira, Yetiş Gültekin, Sophie Steinbuch, Muhammad Bin Munim, Diya Ramesh, Sophie Honeder, Ashwin Kumar, Michelle Wu, Jacob Hansen, Anna Shevzov-Zebrun, Edrees Rashan, Kian Eghbalian, Sharanya Sivanand, Anna Barbeau, Lisa Riedmayr, Mark Duquette, Ahmed Ali, Nicole Henning, Sonia Trojan, Millenia Waite, Tenzin Kunchok, Mayu Nakano, Matthew Vander Heiden
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More posts featuring Julio Aguirre-Ghiso.