Julie Magarian Blander, Scientist and Professor at Weill Cornell Medicine, shared a post by Jonathan Lim, Lead of RISE Consortium, on LinkedIn, adding:
“Jonathan Lim, Caetano Reis e Sousa and colleagues show cDC1s and DNGR1 favor ‘tethered’ neoantigens from F-actin proteins (FABP), trapping them in necrotic debris for better cross-presentation.
Extends Schreiber’s immunoediting.
This new understanding calls for prioritizing FABP derived antigens for cancer vaccines or even perhaps purposefully tethering known neoantigens to F-actin.
Check out the original paper in Nature Immunology.”
Quoting Jonathan Lim’s post:
“Thanks so much Julie Magarian Blander and Atimukta Jha for this really nice News and Views piece on our work.
It means a great deal to see our study discussed in such a clear, insightful way – placing the findings in a broader conceptual context and highlighting the implications for dendritic cell biology, cross-presentation, and tumour immunoediting.”
Title: Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity.
Authors: Kok Haw Jonathan Lim, Oliver Schulz, Irene Lobon, Tomas Castro-Dopico, Luis Zapata, Evangelos Giampazolias, Bruno Frederico, Carlos A. Castellanos, Michael D. Buck, William Stainier, Probir Chakravarty, Gavin Kelly, Neil C. Rogers, Ana Cardoso, Sonia Lee, Brian Vash, Stephanie Maiocco, Raj Mehta, Jessica Strid, Samra Turajlić and Caetano Reis e Sousa.
You can read the Full Article in Nature Immunology.
More posts featuring Jonathan Lim.