Josiah Allen, Precision Medicine Pharmacist at St. Elizabeth Healthcare, shared a post on LinkedIn:
“Great to see St. Elizabeth Healthcare featured in GenomeWeb today!
The article highlights our move to in-house PGx testing (21-gene panel launching by year-end). We are eagerly anticipating our go-live, but I also want to share what didn’t make the final cut for the interview—because it’s also stuff I’m excited about!
We’re not just testing genes. We’re building infrastructure:
- 117 genomic indicators and 200+ alerts in Epic, with tiered warning systems designed to combat alert fatigue (red hard-stops for clopidogrel, soft alerts for PPIs)
- Pharmacist review of every PGx test ordered in the system
- Quarterly reviews to keep everything clinically relevant
We’re making DPYD work the way it should:
- Testing as standard practice since 2022 (before recent NCCN/FDA changes)
- Active protocols and alert systems to ensure appropriate dose reductions
- Active dose titration management by our precision oncology pharmacist, addressing the study findings that most patients never get appropriately titrated
We’re expanding the definition of pharmacogenomics:
- Alerting for FBN1 (Marfan) + fluoroquinolones, RET + GLP-1 agonists, and other genetic conditions with pharmacotherapy implications
- Identifying ALPL mutations causing misdiagnosed ‘osteoporosis’ leading to inappropriate prescriptions of first line agents like alendronate
- Pharmacist review of every clinical genetics finding for pharmacotherapy implications
And we’re building the field itself:
- Studying Kentucky’s biomarker bill effectiveness
- Leading the PGx board certification initiative
- Training the next generation through our PGY2 Clinical Pharmacogenomics residency
This is what comprehensive precision medicine looks like. Not just testing—transformation!
Proud to work with Nihal El Rouby, Jaime Grund, Mayeesha Ahmed Feldman, James (JP) Canner, Jordan Brady, Kendall Billman, Kristen Sund, Mollie Beck, BCOP Tiffany Childers and the rest of this this phenomenal team.
Jaime Grund, Director of Precision Medicine and Breast Centers at St. Elizabeth Healthcare, shared this post, adding:
“Look what happens when the right people are working together in the right place!
Unique strengths and skill sets, one shared purpose… our diversity has become our superpower.
I could not be prouder of our entire Precision Medicine and Genomic Health team!”
More posts featuring St. Elizabeth Healthcare.