Jordan Gauthier, Associate Professor at Fred Hutch, shared a post on X:
“Important Shift in Cytopenia Grading: CTCAE v6.0 Update
If you are a PI running Hematology or Oncology trials, note these key changes in the new CTCAE v6.0 vs v5.0:
General Trend: ‘Downgrading’ of severity. Many counts that were previously Grade 3/4 are now lower grades.
Neutrophils:
- Grade 1 Gone: ANC 1000–1500 is now Grade 1 (was G2). The old Grade 1 (1500–LLN) is no longer graded.
- Stricter G4: threshold drops from <500 to <100/mm³.
Platelets (Thrombocytopenia):
- Wider G3: Now covers 10k–50k (previously 25k–50k).
- Stricter G4: threshold drops from <25k to <10k/mm³.
v6.0 also adds ‘transfusion indicated’ to Grade 3 and ‘urgent intervention indicated’ to Grade 4 criteria.
Overall, IMO these new thresholds align better with clinical practice.”
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