Jean-Charles Soria, SVP and Oncology Therapeutic Area Head at Amgen, shared a post on LinkedIn about a recent article by Wubing Zhang et al, published in Nature:
“Liquid biopsy can now profile the tumor microenvironment (TME)
- Deep-learning analysis of cfDNA methylation profiles inferred spatial TME ecosystems directly from plasma
- Plasma-derived ‘liquid ecotypes’ captured distinct immune/stromal ecosystems linked to geography within tumors (margin vs core)
- Liquid TME profiling predicted ICB response: immune-active SE7/SE8 to benefit; stromal/hypoxic SE4 to resistance
- In melanoma, liquid ecotypes showed stronger survival associations than PD-L1 or TMB in several analyses
- This enables a new paradigm: serial, non-invasive monitoring of the evolving TME ecosystem during therapy.”
Title: Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Authors: Wubing Zhang, Erin Brown, Abul Usmani, Noah Earland, Minji Kang, Chibuzor Olelewe, Anushka Viswanathan, Pradeep Chauhan, Chloé Steen, Hyun Jeon, Susanna Avagyan, Irfan Alahi, Nicholas Semenkovich, Janella Schwab, Chloe Sachs, Faridi Qaium, Peter Harris, Qingyuan Cai, Andrew Gentles, James Knight, Rondell Graham, Antonietta Bacchiocchi, Peter Lucas, Ryan Fields, Mario Sznol, Ruth Halaban, David Chen, Aadel Chaudhuri, Aaron Newman
Read the Full Article on Nature.
More posts featuring Jean-Charles Soria.
