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Jarushka Naidoo: MTAP Loss in Solid Tumors Based on Comprehensive Genomic Data
Jarushka Naidoo/X

Jarushka Naidoo: MTAP Loss in Solid Tumors Based on Comprehensive Genomic Data

Jarushka Naidoo, Consultant Medical Oncologist at Beaumont Hospital and Full Professor at Royal College of Surgeons in Ireland, shared a post on X:

“MTAPloss is an emerging therapeutic target, how common is it/how do we test for it?

  • 409755 tissue, 85801 liquid NGS, F1
  • Prevalence MTAPloss, all solids: 11.4% (meso 32.8%, glioma 32.7%)
  • LBx approx tissue if ctDNA TF ≥20%
Title: Genomics of MTAP Loss in >500,000 Solid Tumor Specimens Profiled Using Comprehensive Genomic Profiling Platforms

Authors: Dean C. Pavlick, Shruthi Rengarajan, Jessica K. Lee, Deter X. Jin, Garrett M. Frampton, Bernard J. Fendler, Andrej Savol, Ole Gjoerup, Hanna Tukachinsky, Richard S.P. Huang, Alexa B. Schrock, Jeffrey S. Ross, Andrea Necchi

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Jarushka Naidoo

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Alexa B. Schrock Andrea Necchi Andrej Savol Bernard J. Fendler cancer Dean C. Pavlick Deter X. Jin Garrett M. Frampton Hanna Tukachinsky Jarushka Naidoo JCO Precision Oncology Jeffrey S. Ross Jessica K. Lee MTAPloss Ole Gjoerup OncoDaily Oncology Richard S. P. Huang Shruthi Rengarajan