Gustavo Monnerat, Deputy Editor at The Lancet, shared a post on LinkedIn:
”5 years. That’s how early a 14-protein blood test predicts lung cancer in a new Cell paper.
- The model was built on 48,099 UK Biobank participants, validated in 8 independent cohorts, and reached AUC 0.865
- The proteins are tied to air pollution exposure (PM2.5 exposure), IL-1β signaling, and oncogenic mutations.
In a retrospective re-analysis of CANTOS, individuals with a high signature score had an Number needed to trea of 55 to prevent one lung cancer case with anti-IL-1β therapy.
Caveat:
The CANTOS analysis is exploratory. Prospective validation still needed before any clinical use.
Ref: Pandya et al., Cell 2026.”
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