Sylvester Comprehensive Cancer Center shared a post on LinkedIn:
“Scientists at Sylvester Brain Tumor Institute have made a breakthrough in understanding glioblastoma, the deadliest brain cancer.
Using advanced imaging, researchers mapped tumor cells in their original locations—something never done before.
The discovery: glioblastoma cells that remain clustered are less aggressive, while dispersed cells pose the greatest threat.
These dispersed cells are highly plastic—able to shift into different forms, resist treatment and drive poor outcomes. Until now, what fueled this plasticity was a mystery.
‘There has never really been an integrated explanation as to why cancer cells develop plasticity,’ said Dr. Iavarone. ‘That’s what our study does. We’ve now revealed how the plasticity of glioblastoma cells is controlled.’
The study, led by Drs. Antonio Iavarone and Anna Lasorella was published Sept. 18 in Cancer Cell and opens the door to new treatment possibilities.
Learn more about their groundbreaking work.”
Title: Restraint of cancer cell plasticity by spatial homotypic clustering
Authors: Simona Migliozzi, Bruno Adabbo, Luciano Garofano, Fan Wu, Pedro Davila, Ricardo J. Komotar, Michael E. Ivan, Ashish H. Shah, Benjamin B. Currall, Sion Williams, Daniel Bilbao Cortes, Melinda Minucci Boone, Macarena I. de la Fuente, Sakir H. Gultekin, Michele Ceccarelli, Antonio Iavarone, Anna Lasorella
Read the Full Article on Cancer Cell
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