Ginny Mason, Executive Director of the Inflammatory Breast Cancer Research Foundation, shared Bisrat Godefay Debeb‘s post on LinkedIn, adding:
“Important work in Inflammatory Breast Cancer! Thank you Bisrat Godefay Debeb from the IBC Patient Population!”
Quoting Bisrat Godefay Debeb‘s post:
“Excited to share our latest work just published in Neuro-Oncology uncovering a new role for soluble E‑cadherin in promoting brain metastasis in inflammatory breast cancer. Our study shows that soluble E-cadherin helps cancer cells resist cell death and triggers reactive astrocytes in the brain microenvironment through the CXCR2 signaling pathway, revealing a key mechanism that could help guide future therapies.
This work was led by the talented Dr. Xiaoding Hu, an Instructor in my lab, who has done an outstanding job driving this project forward. A huge thank you to our amazing team of collaborators for their significant contributions and to the DoD Breast Cancer Research Program, METAvivor, the American Cancer Society, MD Anderson, and the State of Texas for supporting this work.”
Title: Soluble E-cadherin–CXCL1–CXCR2 Axis as a Therapeutic Vulnerability in Inflammatory Breast Cancer Brain Metastasis
Authors: Xiaoding Hu, Yun Xiong, Emilly S Villodre, Huimin Zhang, Isabella R Longa, Juhee Song, Natalie Fowlkes, Savitri Krishnamurthy, Marissa Rylander, Chandra Bartholomeusz, Debu Tripathy, Wendy A Woodward, Junjie Chen and Bisrat G Debeb
Read the full paper here
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