Fran Prenen, Postdoctoral researcher at Harvard Medical School, shared on LinkedIn:
“Very excited to share the first research paper from the Mills group is now published in Nature Metabolism!
This study we show that macrophage-derived itaconate acts as a paracrine signal that suppresses brown adipose tissue thermogenesis by competing with the pro-thermogenic metabolite succinate for uptake through the MCT1 transporter. By limiting succinate uptake into brown adipocytes, macrophages directly restrain mitochondrial respiration and heat production. Revealing an intriguing form of metabolic communication between immune cells and adipose tissue!
Congratulations to Jiayin Tang, Prof. Evanna Mills, and our entire team at Harvard Medical School and Dana-Farber Cancer Institute! This paper was a true team effort, and it was a pleasure to contribute to the project. Stay tuned for many more discoveries to come from the Mills Lab!”
Title: Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis
Authors: Jiayin Tang, Gerard Pernes, Brenda Nakagaki, Nhien Tran, Laura Bokor, Fran Prenen, Mingyang Yi, Avery E. Robertson, Rachel Cronin, Mohamad Sarmini, Jacob Pierscianowski, Victoria Roberts, Birgitta A. Ryback, Carl D. Novina, Karine Auclair, Haopeng Xiao, Evanna L. Mills
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