Federico Pio Fabrizio, Associate Professor in Molecular Biology at Kore University of Enna, shared an article he authored, published in the International Journal of Molecular Sciences:
“Lung cancer remains a major cause of cancer mortality, and its clinical course is often complicated by recurrence and metastasis. A key contributor to these events is cellular dormancy, a reversible, non-proliferative state that allows tumor cells to evade therapy and persist for long periods.
Dormancy in both NSCLC and SCLC is regulated by several mechanisms, including autophagy, stress responses, microenvironmental factors, and especially epigenetic alterations such as DNA methylation, histone modifications and non-coding RNAs, which suppress proliferative programs and maintain quiescence. Dormant cells exhibit unique epigenomic signatures that may serve as biomarkers for minimal residual disease and relapse prediction.
The purpose of this review is to synthesize current knowledge on the epigenetic regulation of dormancy in lung cancer, highlight its interactions with oncogenic signaling pathways, and present emerging therapeutic targets and experimental drugs under evaluation. By clarifying these mechanisms, the review aims to support the development of new strategies to prevent relapse and improve long-term outcomes for lung cancer patients.”
Title: Unlocking Lung Cancer Cell Dormancy: An Epigenetic Perspective
Author: Federico Pio Fabrizio
You can read the Full Article in the International Journal of Molecular Sciences.
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