Federico Pio Fabrizio, Associate Professor in Molecular Biology at Kore University of Enna, shared a post on LinkedIn about an article he co-authored with colleagues published in Frontiers-Molecular and Cell Biology.
“I’m excited to share our latest research, published in Frontiers-Molecular and Cell Biology, exploring SPARC promoter hypermethylation as a potential epigenetic biomarker in Idiopathic Pulmonary Fibrosis (IPF).
Our study demonstrates a significant increase in SPARC promoter methylation in IPF vs. non-IPF lung tissues, supporting its potential role in disease pathogenesis and as a diagnostic marker.
We also provide preliminary functional evidence linking methylation-driven silencing of SPARC expression, highlighting a possible molecular axis between IPF and lung cancer. More work is needed but these findings bring us a step closer to understanding the epigenetic landscape of fibrotic lung disease.
I would also like to express my gratitude to all the collaborators who participated in this project, with a special mention for Dr. Muscarella.”
Title: SPARC aberrant methylation in idiopathic pulmonary fibrosis: an explorative study
Authors: Federico Pio Fabrizio, Angelo Sparaneo, Flavia Centra, Francesco Delli Muti, Paola Parente, Massimiliano Copetti, Marco Donatello Delcuratolo, Antonio Rossi, Elisa Gili, Giulio Rossi, Paolo Graziano, Lucia Anna Muscarella
Read The Full Article on Frontiers-Molecular and Cell Biology.
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