Diego A. Díaz-García, Medical Oncologist /CEO/Founder at CánCare – High Specialty in Oncology, shared a post on X:
“NRG1 Fusions in NSCLC.
In a real-world cohort of 1,536 non-squamous NSCLC cases evaluated with paired DNA/RNA NGS, NRG1 fusions were detected in 0.8%, higher than historical estimates.
Most cases were invasive mucinous adenocarcinomas, PD-L1 negative and TMB-low. Metastatic patients without access to targeted therapy had a median OS of only 7.9 months.
RNA sequencing matters.”
Title: Increased detection of NRG1 fusions in non-squamous non–small cell lung cancer using combined DNA and RNA sequencing in a real-world cohort
Authors: Breno Araújo, Filipe Visani, Rafael Paes, Christopher Negrete, Nathalia Correa, Fernanda Koyama, Jéssica Vieira de Assis, Luciana Valverde, Carolina Fernandes, Clarissa Mathias, Mariana Laloni, Ana Gelatti, Tatiane Montella, Carlos Ferreira, William William, Rodrigo Dienstmann
Read the Full Article.
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