Derek Johnson, Chair, Division of Nuclear Medicine at Mayo Clinic Rochester, shared a post on LinkedIn about a paper by Ramon F. Barajas et al. published in the American Journal of Radiology:
“Last week we crossed a minor milestone at Mayo Clinic Rochester and in my tiny professional niche as a nuclear medicine/neuroradiology/neuro-oncology physician; the first ‘clinical’ amino acid PET performed in a patient with brain tumor.
Despite well over a decade FDOPA use and a more recent FET IND at Mayo Clinic Rochester, our previous experience was entirely for research under IRB-approved protocols or occasional single patient INDs.
Cause for celebration?
Maybe, but I’m having a hard time working up much enthusiasm.
We performed an off-label study with fluciclovine, a PET agent currently approved for use in prostate cancer but not brain tumors.
I was glad to have the option, and appreciate the great work that people like Ali Nabavizadeh and Jana Ivanidze have done in this area, but can’t help but feel like US brain tumor patients and clinicians are long overdue for an FDA approved agent that will allow us to really expand this practice!
Fingers crossed for progress in 2026.”
Title: Clinical Utility of [F18]-Fluciclovine PET/MRI for Differentiating True Progression from Treatment-Related Changes in Patients with Glioblastoma.
Authors: Jana Ivanidze, Kellen Vo Vu, Rongwei Fu, Andrew Brandmaier, Laszlo Szidonya, Gagandeep Choudhary, Jay Starkey, Tony J. Wang, Michael Sisti, L. Guy McKhann, Sushant Puri, Marcus Konner, Michelle Roytman, Eaton Lin, Andrew Kuhn, Joseph R. Osborne, Philip E. Stieg, Kathryn Beal, Rohan R. Ramakrishna, Gagandeep Singh, Angela Lignelli-Dipple, Mikhail Doubrovin, Anh Huan Vo, Mary Welch, Fabio Iwamoto, Aya Haggiagi, Laura Donovan, Maria Diaz, Brian Gill, Benjamin Liechty, David J. Pisapia, Josh Walker, Rajiv S. Magge, Matthew Wood, Valentina Marulanda Corzo, Olabisi R. Sanusi, Ahmed Raslan, Aclan Dogan, Stephen Bowden, Sadek A. Nehmeh, Joshua Nickerson, Nadine Mallak, Amber Ruiz, Prakash Ambady, Ali Nabavizadeh and Ramon F. Barajas.
You can read the full article in the American Journal of Radiology.
More posts featuring Derek Johnson.