David Barbie, Chief of Thoracic Oncology at Dana-Farber Cancer Institute, shared a post on LinkedIn.
“Adding to the growing mechanisms of tumor cell STING suppression, Zehua Li in the laboratory discovered that PTPN2 mediated suppression of IFNgamma signal transduction acts as a novel cell intrinsic mechanism of STING transcriptional repression. Part of a great collaboration with Ravi Uppaluri and Rob Manguso.”
Title: PTPN2 inhibition unleashes response to STING agonism in head and neck squamous cell cancer
Authors: Zehua Li, Cong Fu, Kartik Sehgal, Ann Marie Egloff, Tran Thai, Omar Avila Monge, Cun Lan Chuong, Yaiza Senent, Maia Shea Lineberry, Benjamin Eschle, Koji Haratani, Elena Ivanova, Marco Campisi, Navin Mahadevan, John Quadarella, Patrick Gedeon, Jonathan Schoenfeld, Michihisa Kono, Caroline Fahey, Chayapatou Chayawatto, Kenneth Ngo, Cloud Paweletz, Prafulla Gokhale, Robert Manguso,
Ravindra Uppaluri, David Barbie
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