Danish Cancer Institute shared on LinkedIn:
“News!
New insights into a brake on cell growth.
For cells to grow and divide, events need to happen in the right order. When that control breaks down, cells can continue to grow – one of the hallmarks of cancer. New research from Professor Jakob Nilsson’s lab reveals how one of the proteins involved in this process is regulated.
The study, led by ph.d. student Iker Benavides Puy, focuses on a protein called FAM122A, which helps control when cells enter mitosis, the stage of the cell cycle when one cell divides into two. FAM122A also influences how cells respond to chemotherapeutic agents currently being tested in clinical trials.
Using genetic, cell-based and biochemical approaches, the team found that phosphorylation, the addition of a phosphate group, changes FAM122A in a way that allows it to inhibit a major tumour suppressor. When the researchers prevented this modification, cells struggled to enter mitosis efficiently.
The work has been published in European Journal of Cell Science.”
Title: FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism
Authors: Iker Benavides-Puy, Suzanne Vigneron, Arminja N. Kettenbach, Thierry Lorca, Jakob Nilsson
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