Daniel Auclair, President of Hematocure, shared a post on X about a paper by Nizar J. Bahlis et al published in Nature Medicine:
“Beautiful. Antigenic drift in 68% RRMM cases after anti-GPRC5D TCE driven by:
- Focal to large biallelic deletions of GPRC5D.
- Monoallelic deletion coupled with GPRC5D SNPs or indels on other allele.
- Epigenetic GPRC5D silencing.”
Title: Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma.
Authors: Holly Lee, Sungwoo Ahn, Gerone A. Gonzales, Noemie Leblay, Elie Barakat, Dylan Greening, Pina Colarusso, Johnathan Canton, Sacha Benaoudia, Elham Hasheminasabgorji, Mansour Poorebrahim, David Jung, Marietta Truger, Jihong Jeong, Christine Riedhammer, Hermann Einsele, K. Martin Kortüm, Jan Eckmann, Jitka Somandin, Sara-Sheena Engel, Lawrence H. Boise, Jan Hendrik Frenking, Niels Weinhold, Konstantina Taouxi, Efstathios Kastritis, Sheri Skerget, Deeksha Vishwamitra, Yunje Cho, Francesco Maura, Marc S. Raab, Jill Corre, Leo Rasche, Hervé Avet-Loiseau, Paola Neri and Nizar J. Bahlis.
You can read the whole article in Nature Medicine.
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