Dan-Avi Landau, Professor of Medicine, Weill Cornell Medical College, Core Member, New York Genome Center, shared an article that He and his collugues co-authored on BioRxiv on LinkedIn, adding:
“First linkedin post ever! It’s gone awfully quiet on the other side…..
New pre-print and one I am especially excited about…
Because trees! Big, beautiful trees!
SMART-PTA allows us to collect whole genome+transcriptome of thousands of single cells in the normal human esophagus. Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
Highlights include:
– Immune cell clonal expansion and migration
– Mutational signatures changing throughout life
– Driver acquisition, growth dynamics and impact on phenotype to enhance fitness
– CNVs in normal esophagus
– Massive selection for cnLOH of chr9q with convergent acquisition dozens of times throughout life
– Towards a future where we can track the evolution of the trillions of cells in our body.
Huge kudos to Tamara Prieto, Dennis J. Yuan, John Zinno, Ivan Raimondi and the whole team.
Gratitude to our many collaborators including Julian Abrams, Seishi Ogawa and many more.
Shout out to the incredible Charles Gawad for pioneering PTA and to our friends at BioSkryb Genomics and Ultima Genomics for believing in this vision.
Gratitude also to our funders The Mark Foundation for Cancer Research and the National Cancer Institute (NCI).”
Title: Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus
Authors: Tamara Prieto, Dennis J Yuan, John Zinno, Clayton Hughes, Nicholas Midler, Sheng Kao, Jani Huuhtanen, Ramya Raviram, Fenia Fotopoulou, Neil Ruthen, Srinivas Rajagopalan, Joshua S Schiffman, Andrew R D Avino, Sang-Ho Yoon, Jesus Sotelo, Nathaniel D Omans, Noelle Wheeler, Alejandro Garces, Barun Pradhan, Alexandre Pellan Cheng, Nicolas Robine, Catherine Potenski, Katharine Godfrey, Nobuyuki Kakiuchi, Akira Yokoyama, Seishi Ogawa, Julian Abrams, Ivan Raimondi, Dan A Landau.
Read the full article on BioRxiv.
Read more posts featuring Dan-Avi Landau on OncoDaily.