Daisuke Kotani, GI Medical Oncologist, Chief Physician at the Department of Gastrointestinal Oncology at the National Cancer Center Hospital East, Japan, shared a post on X about a recent article by Lily V.S. Hillson et al, published in Clinical Cancer Research:
“Immunological Dynamics in Rectal Cancer: SCRT vs LCRT
- Circulating lymphocytes: SCRT (less depletion) > LCRT
- Immune cells in TME: SCRT (higher density of CD8+ & FOXP3+) > LCRT, no diff. in FOXP3/CD8 ratio
SCRT is potentially preferred backbone in combination with ICIs.”
Title: Differential Immunological Effects of Short-Course and Long-Course Radiotherapy in Locally Advanced Rectal Cancer
Authors: Lily V.S. Hillson, Ross K. McMahon, Norman J. Galbraith, Ashley K. McCulloch, Chia Yew Kong, Walaiphorn Woraharn, Lydia Melissourgou-Syka, Kathryn A.F. Pennel, Jean A. Quinn, Leia Jones, Raheleh Amirkhah, Natalie Fisher, Noori Maka, Aula Ammar, Phimmada Hatthakarnkul, Liang Tang, Annabelle Smith, Simon Milling, Alec C. McDonald, Harikrishnan Nair, Paul G. Horgan, Colin W. Steele, Janet S. Graham, Philip D. Dunne, Joanne Edwards, Sean M. O’Cathail, Campbell S. Roxburgh
Read the Full Article on Clinical Cancer Research
More posts featuring Daisuke Kotani.