Cancer Research Institute (CRI) shared a post on LinkedIn:
“Investigators from UT Southwestern Medical Center, including CRI Lloyd J. Old STAR Dr. Tuoqi Wu, have discovered that increasing the levels of a protein called BACH2 makes engineered cancer-fighting immune cells behave more like stem cells, improving their therapeutic effectiveness. Their research suggests new strategies for improving the efficacy of these immune cells.
“Using a mouse model of solid cancer, we found that programming CAR T cells to acquire stem-like properties during manufacturing significantly enhances their antitumor activity,”
Dr. Wu describes.
“This fine-tuning of CAR T cells may represent a powerful strategy to overcome key barriers in solid tumor immunotherapy.”
Other articles about CRI on OncoDaily.