Clara Llamedo, Clinical Fellow in Cardiology and Cardio-Oncology at Royal Brompton and Harefield Hospitals, shared a post on LinkedIn:
“Best of 2025 in JACC Cardio-Oncology
Cancer and Cardiovascular Disease: Shared Risk Factors, Mechanisms, and Clinical Implications: JACC: Cardio-Oncology State-of-the-Art Review
This State-of-the-Art Review highlights the bidirectional relationship between cancer and CVD:
- Shared risk factors such as aging, obesity, diabetes, hypertension, smoking, and social determinants drive the development of both conditions
- Shared biological mechanisms — including chronic inflammation, oxidative stress, clonal hematopoiesis, epigenetic dysregulation, immune dysfunction, and cellular senescence — link cancer and CVD at a mechanistic level
- Patients with pre-existing CVD have a higher incidence of cancer, while cancer survivors face excess cardiovascular morbidity and mortality, now a leading non-cancer cause of death
- These interactions call for integrated prevention, risk stratification, and longitudinal care
Key message:
Prevention strategies targeting shared pathways may reduce the burden of both cancer and cardiovascular disease simultaneously.”
Title: Cancer and Cardiovascular Disease: Shared Risk Factors, Mechanisms, and Clinical Implications
Authors: Laith Alhuneafat, Avirup Guha, Anne Blaes, and Suma H. Konety
You can read the full article in JACC: Cardio-Oncology.
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