Danish Cancer Institute shared a post on LinkedIn about a paper by Srinivasa P. Kolapalli et al. published in Science Advances:
“Scientific Achievements in 2025.
Continuing our 2025 highlights: A key player in cellular recycling and liver health.
Recent research from the Danish Cancer Institute uncovers a crucial role for the E3 ligase Pellino 3 (PELI3) in autophagy – the process that allows cells to recycle nutrients during stress. This activity helps maintain lipid balance in the liver, protecting against harmful fat accumulation, which can lead to liver cancer.
The findings also provide important information for diseases such as cancer, where cellular stress responses play a critical role.
In this video, Lisa Frankel explains more.”
Proceed to the video attached to the post.
Title: Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis
Authors: Srinivasa P. Kolapalli, Carsten J. Beese, Steven E. Reid, Sólveig H. Brynjólfsdóttir, Maria H. Jørgensen, Ashish Jain, Joyceline Cuenco, Monika Lewinska, Ahmad Abdul-Al, Aida R. López, Marja Jäättelä, Kei Sakamoto, Jesper B. Andersen, Kenji Maeda, Tor E. Rusten, Anders H. Lund, and Lisa B. Frankel
You can read the Full Article in Science Advances.
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