Carlos Guimarães, Assistant Researcher at 3B´s Research Group, shared a post on LinkedIn:
“Fighting cancer with… Fat?! Cool work in Nature Biotech (Springer Nature) shows how fat cells (adipocytes) can be engineered to outcompete cancer cells for nutrients and suppress disease progression:
Tumors depend on aggressive nutrient uptake to sustain growth. The author’s strategy, adipose manipulation transplantation (AMT), uses engineered adipocytes to outcompete tumors for nutrients, significantly reducing tumor growth in breast and pancreatic cancer models, while reducing angiogenesis and hypoxia.
Patient-derived cancer organoids also showed reduced proliferation when co-cultured with these adipocytes.
Pretty clever way to locally starve cancer cells! I also like how the authors employed 3D in vitro models to derive their conclusions, alongside in vivo ones.
Link to the paper in the Journal’s latest issue: check it out.”
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