Tomasz M. Grzywa: How Can We Make CAR-T Therapy More Durable and Effective?
Tomasz M. Grzywa, Postdoctoral Associate at Children’s Hospital of Philadelphia, shared a post on LinkedIn about an article he and his colleagues authored published in Nature Biomedical Engineering:
”Our new paper has just been published in Nature Biomedical Engineering!
How can we make CAR-T therapy more durable and effective?
CAR-T cell therapy has changed the lives of many patients with blood cancers. However, one big challenge remains: many patients relapse because the CAR-T cells don’t last long enough or stop working over time.
In our study, we developed a vaccine-like approach that gives CAR-T cells a “boost” inside the body. By using specially designed synthetic peptides (mimotopes), we were able to help CAR-T cells expand, persist, and fight cancer more effectively.
Key highlights:
- We developed a general strategy to identify and optimize mimotopes for any CAR using yeast surface display + directed evolution.
- We demonstrated that CAR-T vaccines significantly boost CAR-T expansion, persistence, and memory in both mouse and humanized leukemia models.
- Achieved better leukemia control compared to CAR-T therapy alone.
This approach opens the door to applying vaccine boosting across diverse CAR-T products, offering hope for more effective and long-lasting cancer therapies.”
Title: Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells
Authors: Tomasz M. Grzywa, Alexandra Neeser, Ranjani Ramasubramanian, Anna Romanov, Ryan Tannir, Naveen K. Mehta, Benjamin Cossette, Duncan M. Morgan, Beatriz Goncalves, Ina Sukaj, Elisa Bergaggio, Stephan Kadauke, Regina M. Myers, Luca Paruzzo, Guido Ghilardi, Austin Cozzone, Stephen J. Schuster, Noelle Frey, Libin Zhang, Parisa Yousefpour, Wuhbet Abraham, Heikyung Suh, Marco Ruella, Stephan A. Grupp, Roberto Chiarle, K. Dane Wittrup, Leyuan Ma, Darrell J. Irvine
Read the Full Article.
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